Uptake of 67Ga into the rat liver after treatment with thioacetamide.

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Uptake of 67Ga in the regenerating rat liver and its relationship to lysosomal enzyme activity.

The uptake of 67Ga citrate has been studied in the regenerating rat liver over a period up to 72 hr after partial hepatectomy. The concentration of 67Ga was found to be maximal (four times that of controls) 42 hr after hepatectomy. This was shown to be related to lysosomal enzyme activity rather than to specific phases of the cell cycle, there being a highly significant correlation (p smaller t...

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Effect of Thioacetamide on Rat Liver Regeneration

The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 mg./100 gm. body weight for 7 to 10 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins o...

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Effect of Thioacetamide on Rat Liver Regeneration

The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 rag./100 gm. body weight for 7 to I0 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins ...

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The Effect of Thioacetamide on Rat Liver Regeneration

Partial hepatectomy initiates a complex pattern of cellular changes in the parenchymal cells of the residual liver. The sudden shift of the cell population from normal functional biosyntheses toward syntheses in preparation for cell division provides an ideal system for the study of various aspects of cell metabolism. The morphological and biochemical changes associated with liver restoration h...

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ژورنال

عنوان ژورنال: RADIOISOTOPES

سال: 1984

ISSN: 1884-4111,0033-8303

DOI: 10.3769/radioisotopes.33.9_617